in spite of+名词、代词、名词性从句（宾语从句）。如：He stuck to his own opinion in spite of what I had said.
例句
1、In spite of his age, he still leads an active life.
尽管年事已高，他依旧过着一种忙碌的生活。
2、She is still very active, in spite of her advancing years.
她尽管年事渐高，仍然十分活跃。
3、They went swimming in spite of all the danger signs.
他们无视所有那些危险水域告示牌，还是去游泳了。
4、In spite of what happened, he never lost the will to live.
尽管如此遭遇，他从未丧失活下去的意志。
5、The Derby will be run in spite of the bad weather.
尽管天气恶劣，德比马赛仍将举行。